My research is aiming at the establishment of the practical material supply system by heterologous expression of the marine natural products biosynthetic genes cloned from various marine samples. For the research, I am using a metagenomic approach for marine environmental samples and marine invertebrates which contain a large number of unculturable microorganisms. In addition, in order to achieve the goal, we develop the efficient acquisition method of marine metagenomic DNA and screening method for interesting genes. A functional analysis of the cloned genes is also conducted, and we diversify the products by gene modification. Moreover, a study of the chemical communication of microbial flora under the functional metagenomic method is also performed.