Research Outline

My research tackles antimicrobial resistance (AMR) through three interconnected themes under a One Health framework – an approach that recognizes the interdependence of human, animal, and environmental health and calls for collaborative, cross-sector action to prevent and control infectious diseases on a global scale.
The first theme examines the origins and transmission routes of resistance genes in clinically important bacteria – including Pseudomonas aeruginosa, Klebsiella pneumoniae, and Salmonella – across companion animals, humans, and the environment in Japan and globally.
The second theme challenges the assumption that acquiring resistance necessarily elevates health risk, exploring whether resistance determinants can paradoxically attenuate bacterial virulence.
The third theme aims to identify novel therapeutic strategies and alternatives to conventional antibiotics by examining whether non-antibiotic compounds, particularly plant-derived polyphenols, can be leveraged alongside targeted gene inhibitors to combat resistant bacterial infections.